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Nioxin System 5 for Medium/Coarse, Natural, Normal to Thin-Looking Hair. This is 3-Part System contains the following ingredients to help regrow hair. SmoothPlex™ provides moisture, natural shine and smooth control to hair. Activ-Renewal™ delivers bionutrients for a more youthful-looking scalp and fuller, healthier-looking hair. Transactive Delivery System™ delivers essential nutrients onto the scalp which improves the appearance of thinning hair and creates an environment for fuller, healthier-looking hair.