Used nightly from beginning. Had a tinge of sting with PTR day cream first week.
I’ve used for a year and see big improvement with crows feet. Almost gone.
Yes, it bites a little when putting it on, but quickly goes away. After 2 minutes I rinsed it off and my skin was so incredibly smooth. Followed up with PTR new Glow Serum and a good moisturizer. Will repost in a month, but 60 pads will last a while.